Second to fourth digit ratio: its relationship with core cancer volume and Gleason score in prostate biopsy
Int. braz. j. urol
;
38(5): 611-619, Sept.-Oct. 2012. tab
Article
Dans Anglais
| LILACS
| ID: lil-655988
ABSTRACT
OBJECTIVE:
To investigate the relationships between 2nd to 4th digit ratio (digit ratio) and prostate cancer detection rate and biopsy findings, including Gleason score. MATERIALS ANDMETHODS:
In 770 consecutive men aged 40 years or older that presented with lower urinary tract symptoms (LUTS), right hand 2nd and 4th digit lengths were measured prior to PSA determinations, DRE and transrectal ultrasonography (TRUS). Among these, 166 men with a prostate specific antigen (PSA) level ≥ 3 ng/mL or abnormal digit rectal examination (DRE) prospectively underwent prostate biopsies. The relationship between digit ratio and prostate cancer detection rate and biopsy findings was investigated.RESULTS:
The study subjects were allocated to two groups by digit ratio (group A digit ratio < 0.95; n = 420; group B digit ratio ≥ 0.95; n = 350). Despite similar biopsy rates (22.4% vs. 20.6%, p = 0.544), group A had higher cancer detection rate (46.8% (44/94) vs. 23.6% (17/72), p = 0.002; OR = 2.847, 95% CI = 1.445-5.610). When we analyzed 408 positive biopsy cores (group A digit ratio < 0.95, n = 282; group B digit ratio ≥ 0.95, n = 126), group A had higher percentage of core cancer volume (46.7% vs. 37.1%, p = 0.005) and more biopsy cores with high Gleason score (sum of Gleason score ≥ 9 18/282 (6.4%) vs. 1/126 (0.8%), p = 0.010; primary Gleason score = 5 12/282 (4.3%) vs. 0/126 (0.0%), p = 0.021).CONCLUSIONS:
A lower digit ratio is related to an increased detection rate of prostate cancer, a high percentage of core cancer volume and a high Gleason score.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Prostate
/
Tumeurs de la prostate
/
Antigène spécifique de la prostate
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Int. braz. j. urol
Thème du journal:
Urologie
Année:
2012
Type:
Article
Pays d'affiliation:
Corée du Sud
Institution/Pays d'affiliation:
Gachon University Gil Hospital/KR
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