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In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon
Silva, Luiz Francisco Rocha e; Magalhães, Pedro Melillo de; Costa, Mônica Regina Farias; Alecrim, Maria das Graças Costa; Chaves, Francisco Célio Maia; Hidalgo, Ari de Freitas; Pohlit, Adrian Martin; Vieira, Pedro Paulo Ribeiro.
  • Silva, Luiz Francisco Rocha e; Instituto Nacional de Pesquisas da Amazônia. Laboratório de Princípios Ativos da Amazônia. Manaus. BR
  • Magalhães, Pedro Melillo de; Universidade Estadual de Campinas. Paulínia. BR
  • Costa, Mônica Regina Farias; Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus. BR
  • Alecrim, Maria das Graças Costa; Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus. BR
  • Chaves, Francisco Célio Maia; Embrapa Amazônia Ocidental. Manaus. BR
  • Hidalgo, Ari de Freitas; Universidade Federal do Amazonas. Manaus. BR
  • Pohlit, Adrian Martin; Instituto Nacional de Pesquisas da Amazônia. Laboratório de Princípios Ativos da Amazônia. Manaus. BR
  • Vieira, Pedro Paulo Ribeiro; Universidade do Estado do Amazonas. Manaus. BR
Mem. Inst. Oswaldo Cruz ; 107(7): 859-866, Nov. 2012. ilus, graf, tab
Article Dans Anglais | LILACS | ID: lil-656040
ABSTRACT
Artemisinin is the active antimalarial compound obtained from the leaves of Artemisia annua L. Artemisinin, and its semi-synthetic derivatives, are the main drugs used to treat multi-drug-resistant Plasmodium falciparum (one of the human malaria parasite species). The in vitro susceptibility of P. falciparum K1 and 3d7 strains and field isolates from the state of Amazonas, Brazil, to A. annua infusions (5 g dry leaves in 1 L of boiling water) and the drug standards chloroquine, quinine and artemisinin were evaluated. The A. annua used was cultivated in three Amazon ecosystems (várzea, terra preta de índio and terra firme) and in the city of Paulínia, state of São Paulo, Brazil. Artemisinin levels in the A. annua leaves used were 0.90-1.13% (m/m). The concentration of artemisinin in the infusions was 40-46 mg/L. Field P. falciparum isolates were resistant to chloroquine and sensitive to quinine and artemisinin. The average 50% inhibition concentration values for A. annua infusions against field isolates were 0.11-0.14 μL/mL (these infusions exhibited artemisinin concentrations of 4.7-5.6 ng/mL) and were active in vitro against P. falciparum due to their artemisinin concentration. No synergistic effect was observed for artemisinin in the infusions.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Plasmodium falciparum / Extraits de plantes / Artemisia annua / Antipaludiques Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 2012 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Embrapa Amazônia Ocidental/BR / Fundação de Medicina Tropical Heitor Vieira Dourado/BR / Instituto Nacional de Pesquisas da Amazônia/BR / Universidade Estadual de Campinas/BR / Universidade Federal do Amazonas/BR / Universidade do Estado do Amazonas/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Plasmodium falciparum / Extraits de plantes / Artemisia annua / Antipaludiques Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 2012 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Embrapa Amazônia Ocidental/BR / Fundação de Medicina Tropical Heitor Vieira Dourado/BR / Instituto Nacional de Pesquisas da Amazônia/BR / Universidade Estadual de Campinas/BR / Universidade Federal do Amazonas/BR / Universidade do Estado do Amazonas/BR