Your browser doesn't support javascript.
loading
A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin
Ramos, Juliene Antonio; Ramos, Ana Lúcia de Araújo; Hoffmann, Luisa; Perez, Renata de Mello; Coelho, Henrique Sérgio Moraes; Ürményi, Turán Péter; Silva, Rosane; Rondinelli, Edson; Villela-Nogueira, Cristiane Alves.
  • Ramos, Juliene Antonio; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro. BR
  • Ramos, Ana Lúcia de Araújo; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Faculdade de Medicina. Departamento de Medicina Interna. Rio de Janeiro. BR
  • Hoffmann, Luisa; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro. BR
  • Perez, Renata de Mello; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Faculdade de Medicina. Departamento de Medicina Interna. Rio de Janeiro. BR
  • Coelho, Henrique Sérgio Moraes; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Faculdade de Medicina. Departamento de Medicina Interna. Rio de Janeiro. BR
  • Ürményi, Turán Péter; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro. BR
  • Silva, Rosane; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro. BR
  • Rondinelli, Edson; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro. BR
  • Villela-Nogueira, Cristiane Alves; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Faculdade de Medicina. Departamento de Medicina Interna. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 107(7): 888-892, Nov. 2012. tab
Article Dans En | LILACS | ID: lil-656044
Responsable en Bibliothèque : BR1.1
ABSTRACT
Single nucleotide polymorphisms (SNPs) in the interleukin (IL)28B locus have been associated with a sustained virological response (SVR) in interferon-ribavirin (IFN-RBV)-treated chronic hepatitis C virus (HCV)-infected patients in European and African populations. In this study, the genotype frequency of two IL28B SNPs (rs129679860 and rs8099917) in a cohort of chronic HCV-monoinfected patients in Brazil was evaluated and the SNP sufficient to predict the treatment response outcome was determined. A total of 66 naïve genotype-1 chronic HCV-infected patients were genotyped and the associated viral kinetics and SVR were assessed. The overall SVR was 38%. Both the viral kinetics and SVR were associated with rs129679860 genotypes (CC = 62% vs. CT = 33% vs. TT = 18%, p = 0.016). However, rs8099917 genotypes were only associated with SVR (TT = 53% vs. TG = 33% vs. GG = 18%; p = 0.032). In this population, the analysis of a single SNP, rs12979860, successfully predicts SVR in the IFN-RBV treatment of HCV.
Sujets)


Texte intégral: 1 Indice: LILACS Sujet Principal: Interleukines / Hépatite C chronique / Polymorphisme de nucléotide simple Type d'étude: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Female / Humans / Male Pays comme sujet: America do sul / Brasil langue: En Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: MEDICINA TROPICAL / PARASITOLOGIA Année: 2012 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Interleukines / Hépatite C chronique / Polymorphisme de nucléotide simple Type d'étude: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Female / Humans / Male Pays comme sujet: America do sul / Brasil langue: En Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: MEDICINA TROPICAL / PARASITOLOGIA Année: 2012 Type: Article