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Relationship between plasminogen activator inhibitor type-1 (PAI-1) gene polymorphisms and osteoporosis in Turkish women
Ozgen, Merih; Cosan, Didem Turgut; Doganer, Fulya; Soyocak, Ahu; Armagan, Onur; Gunes, Hasan Veysi; Degirmenci, Irfan; Ozkara, Gulsah Ogutler; Mutlu, Fezan Sahin.
  • Ozgen, Merih; Eskisehir Osmangazi University. Faculty of Medicine. Department of Physical Medicine and Rehabilitation. Eskisehir. TR
  • Cosan, Didem Turgut; Eskisehir Osmangazi University. Faculty of Medicine. Department of Medical Biology. Eskisehir. TR
  • Doganer, Fulya; Eskisehir Osmangazi University. Faculty of Medicine. Department of Medical Biology. Eskisehir. TR
  • Soyocak, Ahu; Eskisehir Osmangazi University. Faculty of Medicine. Department of Medical Biology. Eskisehir. TR
  • Armagan, Onur; Eskisehir Osmangazi University. Faculty of Medicine. Department of Physical Medicine and Rehabilitation. Eskisehir. TR
  • Gunes, Hasan Veysi; Eskisehir Osmangazi University. Faculty of Medicine. Department of Medical Biology. Eskisehir. TR
  • Degirmenci, Irfan; Eskisehir Osmangazi University. Faculty of Medicine. Department of Medical Biology. Eskisehir. TR
  • Ozkara, Gulsah Ogutler; Eskisehir Osmangazi University. Faculty of Medicine. Department of Physical Medicine and Rehabilitation. Eskisehir. TR
  • Mutlu, Fezan Sahin; Eskisehir Osmangazi University. Faculty of Medicine. Department of Biostatistics and Medical Informatics. Eskisehir. TR
Clinics ; 67(11): 1299-1302, Nov. 2012. graf, tab
Article Dans Anglais | LILACS | ID: lil-656721
ABSTRACT

OBJECTIVE:

The development of osteoporosis is associated with several risk factors, such as genetic structures that affect bone turnover and bone mass. The impact of genetic structures on osteoporosis is not known. Plasminogen activator inhibitor type-1 regulates the bone matrix and bone balance. This study assessed the correlation between plasminogen activator inhibitor type-1 gene 4G/5G polymorphisms and osteoporosis in a population of Turkish women.

METHODS:

A total of 195 postmenopausal female patients who were diagnosed with osteoporosis (Group I) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 90 females with no osteoporosis (Group II) were included in this study. Correlations between PAI-1 gene 4G/5G polymorphisms and osteoporosis were investigated through the identification of PAI-1 gene 4G/5G polymorphism genotypes using the polymerase chain reaction.

RESULTS:

No significant differences in the genotype and allele frequency of 4G/5G plasminogen activator inhibitor type-1 polymorphisms were observed between the two groups, and both groups exhibited the most frequently observed 4G5G genotype.

CONCLUSION:

No correlation between the development of osteoporosis in the female Turkish population and 4G/5G plasminogen activator inhibitor type-1 gene polymorphisms was observed.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Polymorphisme génétique / Ostéoporose post-ménopausique / Inhibiteur-1 d'activateur du plasminogène Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adulte très âgé / Femelle / Humains Pays comme sujet: Asie langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2012 Type: Article Pays d'affiliation: Turquie Institution/Pays d'affiliation: Eskisehir Osmangazi University/TR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Polymorphisme génétique / Ostéoporose post-ménopausique / Inhibiteur-1 d'activateur du plasminogène Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adulte très âgé / Femelle / Humains Pays comme sujet: Asie langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2012 Type: Article Pays d'affiliation: Turquie Institution/Pays d'affiliation: Eskisehir Osmangazi University/TR