Hyponatremia, acute kidney injury, and mortality in HIV-related toxoplasmic encephalitis
Braz. j. infect. dis
;
16(6): 558-563, Nov.-Dec. 2012. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-658927
ABSTRACT
BACKGROUND:
There are no reports on hyponatremia and acute kidney injury (AKI) involved in the course of HIV-related toxoplasmic encephalitis (TE). The main objective of this study was to describe the occurrence of hyponatremia and its relationship with AKI and mortality in HIV-related toxoplasmic encephalitis (TE).METHODS:
This was a retrospective cohort study on patients with HIV-related TE. AKI was considered only when the RIFLE (risk, injury, failure, loss, end-stage) criterion was met, after the patient was admitted.RESULTS:
A total of 92 patients were included, with a mean age of 36 ± 9 years. Hyponatremia at admission was observed in 43 patients (46.7%), with AKI developing in 25 (27.1%) patients during their hospitalization. Sulfadiazine was the treatment of choice in 81% of the cases. Death occurred in 13 cases (14.1%). Low serum sodium level correlated directly with AKI and mortality. Male gender (OR 7.89, 95% CI 1.22-50.90, p = 0.03) and hyponatremia at admission (OR 4.73, 95% CI 1.22-18.30, p = 0.02) were predictors for AKI. Independent risk factors for death were AKI (OR 8.3, 95% CI 1.4-48.2, p < 0.0001) and hyponatremia (or 9.9, 95% ci 1.2-96.3, p < 0.0001).CONCLUSION:
AKI and hyponatremia are frequent in TE. Hyponatremia on admission is highly associated with AKI and mortality.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Toxoplasmose cérébrale
/
Infections opportunistes liées au SIDA
/
Atteinte rénale aigüe
/
Hyponatrémie
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. infect. dis
Thème du journal:
Maladies transmissibles
Année:
2012
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de Fortaleza/BR
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