Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
Mem. Inst. Oswaldo Cruz
; 107(8): 1060-1063, Dec. 2012. graf
Article
de En
| LILACS
| ID: lil-660656
Bibliothèque responsable:
BR1.1
ABSTRACT
The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (> 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.
Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Vaccins anti-hépatite B
/
Hépatite B
/
Anticorps de l'hépatite B
Type d'étude:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Adolescent
/
Child
/
Humans
Pays comme sujet:
America do sul
/
Brasil
langue:
En
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2012
Type:
Article