The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Acta cir. bras
;
28(1): 5-9, jan. 2013. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-662341
ABSTRACT
PURPOSE:
To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia.METHODS:
Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol.RESULTS:
Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury.CONCLUSION:
Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Hydroxyéthylamidons
/
Substituts du plasma
/
Atteinte rénale aigüe
/
Ischémie
/
Solution isotonique
/
Rein
Type d'étude:
Guide de pratique
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2013
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
UNESP/BR
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