A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury
Acta cir. bras
;
28(2): 154-159, Feb. 2013. ilus, graf
Article
Dans Anglais
| LILACS
| ID: lil-662365
ABSTRACT
PURPOSE:
To investigate the protective effects of pentoxifylline against lung injury observed after dorsal scald in aged animals.METHODS:
Adult (eight months old) and aged (20 months old) rats were subjected to thermal injury or sham procedure. The six hours post-trauma animals received pentoxifylline and after 24 hours were euthanatized and lung tissue samples collectedted. The bronchoalveolar lavage fluid was evaluated for total protein content and tumor necrosis factor-alpha cytokine. Malondialdehyde and myeloperoxidase activety in the lung homogenate were measured and a histological lung examination was undertaken.RESULTS:
Burn injury induced oxidative stress in lung homogenate was higher in elderly-burned rats compared to adult-burned rats (p<0.001). Total protein and cytokine in bronchoalveolar lavage increased in the elderly-burned group when compared to the adult-burned group (p<0.001). All parameters decreased in bolth groups treated with pentoxifylline (p<0.05).CONCLUSIONS:
The injury was augmented in elderly rats when compared to adult rats. Damage was reduced with the use of pentoxifylline, however further studies are needed to evaluate the dose-response of the drug.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pentoxifylline
/
Piégeurs de radicaux libres
/
Lésion pulmonaire
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2013
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
UNIFESP/BR
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