Gasometric parameters after tracheal aspiration in patients with septic shock: a clinical trial

ABSTRACT

Hypothesis: There is no hypoxemia after tracheal aspiration when there is no optimization of O2 pre-aspiration. Aim: To verify, through the assessment of arterial gasometry, if there is a significant difference in the values of SaO2, PaO2 and P/F in patients on ventilatory assistance and septic shock when FiO2 is not kept to 100% after tracheal aspiration. Methodology: a randomized clinical trial-type crossover, with two interventions, one arm, double-blind, phase III. A convenience sample of 27 patients is used by calculation for discrete variables of finite populations. Inclusion criteria septic shock due to local infection, mechanical ventilation for more than 12 hours, optimal FiO2 <95%, PEEP <24 mmHg. For the statistical analysis we will use the student`s t-test with a significance level of 5% supported by software R version 2.5.1