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Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis
Brazilian Journal of Medical and Biological Research; Munekata, R.V.; Terreri, M.T.R.A.; Peracchi, O.A.B.; Len, C.; Lazaretti-Castro, M.; Sarni, R.O.S.; Hilário, M.O.E..
  • Munekata, R.V.; Universidade Federal de São Paulo. Departamento de Pediatria. Imunologia Clínica e Reumatologia. Unidade de Reumatologia Pediátrica, Divisão de Alergia. São Paulo. BR
  • Terreri, M.T.R.A.; Universidade Federal de São Paulo. Departamento de Pediatria. Imunologia Clínica e Reumatologia. Unidade de Reumatologia Pediátrica, Divisão de Alergia. São Paulo. BR
  • Peracchi, O.A.B.; Universidade Federal de São Paulo. Departamento de Pediatria. Imunologia Clínica e Reumatologia. Unidade de Reumatologia Pediátrica, Divisão de Alergia. São Paulo. BR
  • Len, C.; Universidade Federal de São Paulo. Departamento de Pediatria. Imunologia Clínica e Reumatologia. Unidade de Reumatologia Pediátrica, Divisão de Alergia. São Paulo. BR
  • Lazaretti-Castro, M.; Universidade Federal de São Paulo. Departamento de Pediatria. Imunologia Clínica e Reumatologia. Unidade de Reumatologia Pediátrica, Divisão de Alergia. São Paulo. BR
  • Sarni, R.O.S.; Universidade Federal de São Paulo. Departamento de Pediatria. Imunologia Clínica e Reumatologia. Unidade de Reumatologia Pediátrica, Divisão de Alergia. São Paulo. BR
  • Hilário, M.O.E.; Universidade Federal de São Paulo. Departamento de Pediatria. Imunologia Clínica e Reumatologia. Unidade de Reumatologia Pediátrica, Divisão de Alergia. São Paulo. BR
Braz. j. med. biol. res ; 46(1): 98-102, 11/jan. 2013. tab
Article Dans Anglais | LILACS | ID: lil-665795
ABSTRACT
Our objective was to evaluate the concentrations of serum 25-hydroxyvitamin D [25(OH)D], serum calcium, serum phosphorus, alkaline phosphatase, and parathormone (PTH) in patients with polyarticular juvenile idiopathic arthritis (JIA) and to associate them with disease duration and activity, bone mineral density and use of medications. In a cross-sectional and controlled study, 30 patients with polyarticular JIA were evaluated and compared to 30 healthy individuals matched for age and gender. Clinical status, anthropometry, laboratory markers in both patients and controls, and bone mineral density, only in the patients, were measured. Of the 30 patients included in the study, 23 (76.7%) were female and 16 (53.3%) non-Caucasian; mean age was 14 years (range = 4 to 20 years). Mean disease duration was 5 years (range = 1 to 12 years). The mean concentrations of serum albumin-corrected calcium (9.04 ± 0.41 mg/dL) and alkaline phosphatase (153.3 ± 100.1 IU) were significantly lower in patients with JIA than in controls (P < 0.0001 and P = 0.001, respectively). No differences in 25(OH)D, PTH or serum phosphorus were observed between JIA and control subjects. Regarding 25(OH)D concentration, 8 patients (26.7%) and 5 controls (16.7%) had 25(OH)D concentrations compatible with deficiency (lower than 20 ng/mL) and 14 patients (46.7%) and 18 controls (60%) had concentrations compatible with insufficiency (20-32 ng/mL). These values were not associated with disease activity, use of medications or bone mineral density. We observed a high frequency of 25(OH)D insufficiency and deficiency in the study sample. The compromised bone metabolism emphasizes the importance of follow-up of JIA patients.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Arthrite juvénile / Vitamine D / Os et tissu osseux / Densité osseuse Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Mâle langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2013 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Arthrite juvénile / Vitamine D / Os et tissu osseux / Densité osseuse Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Mâle langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2013 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de São Paulo/BR