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Effect of fractionated radiotherapy on the parotid gland: an experimental study in brazilian minipigs
Stramandinoli-Zanicotti, Roberta Targa; Sassi, Laurindo Moacir; Schussel, Juliana Lucena; Torres, Maria Fernanda; Funchal, Melissa; Smaniotto, Gustavo Henrique; Dissenha, José Luis; Carvalho, Andre Lopes.
  • Stramandinoli-Zanicotti, Roberta Targa; Erasto Gaertner Hospital. Oral and Maxillofacial Surgery Department. Curitiba. BR
  • Sassi, Laurindo Moacir; Erasto Gaertner Hospital. Oral and Maxillofacial Surgery Department. Curitiba. BR
  • Schussel, Juliana Lucena; Erasto Gaertner Hospital. Oral and Maxillofacial Surgery Department. Curitiba. BR
  • Torres, Maria Fernanda; Federal University of Parana. Veterinary Medicine. Curitiba. BR
  • Funchal, Melissa; Erasto Gaertner Hospital. Radiotherapy Department. Curitiba. BR
  • Smaniotto, Gustavo Henrique; Erasto Gaertner Hospital. Curitiba. BR
  • Dissenha, José Luis; Erasto Gaertner Hospital. Oral and Maxillofacial Surgery Department. Curitiba. BR
  • Carvalho, Andre Lopes; University of São Paulo. Hospital de Cancer de Barretos. BR
Int. arch. otorhinolaryngol. (Impr.) ; 17(2): 163-167, Apr.-June 2013. ilus, tab
Article Dans Anglais | LILACS | ID: lil-670354
ABSTRACT

INTRODUCTION:

Radiotherapy (RT) of head and neck neoplasms often damages the salivary glands.

AIM:

To examine the pattern of morphologic changes resulting from RT of the head and neck region in minipig parotid glands in a clinical and experimental research setting.

METHODS:

Twelve 18-month-old male Brazilian minipigs weighing 30-40 kg were selected. Eight minipigs were assigned to the experimental group (group 1) and 4 to the control group (group 2). The RT was performed under general anesthesia at Erasto Gaertner Hospital, Curitiba, Brazil, using an á/â ratio of 2.5. The minipigs from group 1 underwent 3 sessions of irradiation with Cobalt 60 of the head and neck, bilaterally, with 3 exposures of 8 Gy each at 7-day intervals for a total dose of 24 Gy. The animals were sacrificed 12 weeks post-RT.

RESULTS:

The irradiated parotid glands displayed reductions in the size and number of acini as well as loss of secretory granules. The presence of fibrosis and loss of parenchyma relative to non-irradiated glands were observed, with an average reduction in volume of 54%.

CONCLUSIONS:

Our results demonstrate that this model for parotid gland damage resulting from an RT regimen appears to be useful for preclinical large animal studies of RT-induced damage and testing novel potential treatment options. Although recent advances in radiation therapy, such as intensity-modulated radiation therapy, have reduced the dose and limited the field of radiation, considerable salivary gland injury still occurs and can greatly impact the patient's quality of life after cancer treatment.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Glandes salivaires / Tumeurs de la tête et du cou Limites du sujet: Animaux Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Int. arch. otorhinolaryngol. (Impr.) Thème du journal: Otolaryngologie Année: 2013 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Erasto Gaertner Hospital/BR / Federal University of Parana/BR / University of São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Glandes salivaires / Tumeurs de la tête et du cou Limites du sujet: Animaux Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Int. arch. otorhinolaryngol. (Impr.) Thème du journal: Otolaryngologie Année: 2013 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Erasto Gaertner Hospital/BR / Federal University of Parana/BR / University of São Paulo/BR