Molecular half-full mechanisms by phagocityc cells on invasive Aspergilosis / Mecanismos moleculares mediados por celulas fagociticas en la aspergilosis invasiva
Colomb. med
;
43(1): 95-102, Jan.-Mar. 2012.
Article
Dans Anglais
| LILACS
| ID: lil-673549
ABSTRACT
Fungus from the Aspergillus genus mainly affects lung tissue, occurring when the integrity of the host immunesystem is compromised. The human body uses immunocompetence conditions from mechanical and enzymatic defenses and the action of the innate immune system cells and also uses adaptive responses to control infection. Neutrophils, macrophages, and dendritic cells are critical as antifungal effector cells possess surface receptors that recognize fungal structures and trigger specific responses. TLRs and Dectin-1 the most studied for this interaction. TLRs are responsible for the production and release of cytokines and Dectin-1 is essential in the phagocytosis of theparticle recognition and production of ROS. The best-studied cytokines and its crucial role in the response toAspergillus spp. are TNF-á, IFN-ã, and IL-12. In this work, we reviewed the main mechanisms related to molecularreceptors on phagocytic cells involved in the recognition of Aspergillus spp. Understanding the immune response insituations of immunocompetence and its comparison in immunodeficient organisms could provide alternatives tocontrol invasive aspergillosis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Aspergillus
/
Système immunitaire
langue:
Anglais
Texte intégral:
Colomb. med
Thème du journal:
Médicament
Année:
2012
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Universidad Autónoma de Yucatán/MX
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