Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomía / Vascular endothelial growth factor in malignant and non malignant prostatic tissue: Association with tumor recurrence at one year after prostatectomy
Rev. méd. Chile
; 141(2): 153-159, feb. 2013. ilus, tab
Article
de Es
| LILACS
| ID: lil-675055
Bibliothèque responsable:
CL1.1
ABSTRACT
Background:
Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor.Aim:
To search for VEFG in prostatic tissue. Material andMethods:
This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients.Results:
PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p < 0.01). No relationship was found between the percentage of staining and recurrence at one year of follow-up in the case of PC.Conclusions:
These results would rule out VEGF as a prognostic factor in this series of patients.Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Prostate
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Hyperplasie de la prostate
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Tumeurs de la prostate
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Marqueurs biologiques tumoraux
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Facteur de croissance endothéliale vasculaire de type A
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Récidive tumorale locale
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Aged
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Humans
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Male
langue:
Es
Texte intégral:
Rev. méd. Chile
Thème du journal:
MEDICINA
Année:
2013
Type:
Article
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Project document