Gabaergic fibers from substantia nigra para reticulata modulate escape bahavior induced by midbrain central gray stimulation
Braz. j. med. biol. res
;
22(1): 111-4, 1989. ilus
Article
Dans Anglais
| LILACS
| ID: lil-67511
ABSTRACT
Eletrical stimulation or microinjection of GABA antagonists into the dorsal periaqueductal gray (DPAG) produces escape behavior. In order to determine whether the nigrocollicular gabaergic fibers exert some control over this behavior, rats bearing kainic acid lesion of the substantia nigra pars reticulata were submitted to microinjections of bicuculline or electrical stimulation of the DPAG at the escape threshold. Rats thus treated exhibited a significant decrease in the escape threshold while bicuculline increased the expression of flight behavior. These results suggest an inhibitory control of gabaergic fibers from the substantia nigra pars reticulata on aversive behavior induced by DPAG stimulation
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Indice:
LILAS (Amériques)
Sujet Principal:
Comportement fugueur
/
Bicuculline
/
Substantia nigra
/
Acide gamma-amino-butyrique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1989
Type:
Article
/
descriptif de projet
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