Late recognition and illness severity are determinants of early death in severe septic patients
Clinics
;
68(5): 586-591, maio 2013. tab
Article
Dans Anglais
| LILACS
| ID: lil-675763
ABSTRACT
OBJECTIVE:
To identify the independent variables associated with death within 4 days after the first sepsis-induced organ dysfunction.METHODS:
In this prospective observational study, severe sepsis and septic shock patients were classified into 3 groups Group 1, survivors; Group 2, late non-survivors; and Group 3, early non-survivors. Early death was defined as death occurring within 4 days after the first sepsis-induced organ dysfunction. Demographic, clinical and laboratory data were collected and submitted to univariate and multinomial analyses.RESULTS:
The study included 414 patients 218 (52.7%) in Group 1, 165 (39.8%) in Group 2, and 31 (7.5%) in Group 3. A multinomial logistic regression analysis showed that age, Acute Physiology and Chronic Health Evaluation II score, Sepsis-related Organ Failure Assessment score after the first 24 hours, nosocomial infection, hepatic dysfunction, and the time elapsed between the onset of organ dysfunction and the sepsis diagnosis were associated with early mortality. In contrast, Black race and a source of infection other than the urinary tract were associated with late death. Among the non-survivors, early death was associated with Acute Physiology and Chronic Health Evaluation II score, chronic renal failure, hepatic dysfunction Sepsis-related Organ Failure Assessment score after 24 hours, and the duration of organ dysfunction.CONCLUSION:
Factors related to patients' intrinsic characteristics and disease severity as well as the promptness of sepsis recognition are associated with early death among severe septic patients. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Mortalité hospitalière
/
Sepsie
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2013
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Federal University of São Paulo/BR
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