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New frontiers in the study of memory mechanisms
Revista Brasileira de Psiquiatria; Furini, Cristiane R.G.; Myskiw, Jociane C.; Benetti, Fernando; Izquierdo, Ivan.
  • Furini, Cristiane R.G.; Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS). Memory Center. Brain Institute. Porto Alegre. BR
  • Myskiw, Jociane C.; Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS). Memory Center. Brain Institute. Porto Alegre. BR
  • Benetti, Fernando; Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS). Memory Center. Brain Institute. Porto Alegre. BR
  • Izquierdo, Ivan; Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS). Memory Center. Brain Institute. Porto Alegre. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 35(2): 173-177, April-June 2013.
Article Dans Anglais | LILACS | ID: lil-680893
ABSTRACT
We review recent work on three major lines of memory research a) the possible role of the protein kinase M-zeta (PKMzeta) in memory persistence; b) the processes of “synaptic tagging and capture” in memory formation; c) the modulation of extinction learning, widely used in the psychotherapy of fear memories under the name of “exposure therapy”. PKMzeta is a form of protein kinase C (PKC) that apparently remains stimulated for months after the consolidation of a given memory. Synaptic tagging is a mechanism whereby the weak activation of one synapse can tag it with a protein so other synapses in the same cell can reactivate it by producing other proteins that bind to the tag. Extinction, once mistakenly labeled as a form of forgetting, is by itself a form of learning; through it animals can learn to inhibit a response. We now know it can be modulated by neurotransmitters or by synaptic tagging, which should enable better control of its clinical use.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Synapses / Protéine kinase C / Mémoire Limites du sujet: Humains langue: Anglais Texte intégral: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Thème du journal: Psychiatrie Année: 2013 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS)/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Synapses / Protéine kinase C / Mémoire Limites du sujet: Humains langue: Anglais Texte intégral: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Thème du journal: Psychiatrie Année: 2013 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS)/BR