Biomarcadores pronósticos de gravedad del dengue / Biomarkers for the prognosis of severe dengue
Biomédica (Bogotá)
;
33(supl.1): 108-116, set. 2013. graf, tab
Article
Dans Espagnol
| LILACS
| ID: lil-695802
RESUMEN
.
ABSTRACT
Introduction:
There are very few strategies for the early detection of the patients who might develop the severe form of the illness.Objective:
To evaluate the utility of serum levels of some immune response mediators as early biomarkers for the severe dengue prognosis during the early phase of the illness. Materials andmethods:
Using a case-control design nested in a multicenter cohort from the AEDES network (a Colombian multicenter study), we compared TNF a, ST2, TRAIL and IDO levels in samples which were obtained during the early phase of the illness.Results:
ST2, TRAIL and TNF a levels were higher in severe dengue patients compared with uncomplicated patients (p<0.0001), as follows OR=24.8, CI95%= 6.1- 98.0; OR=18.0, CI95%= 4.6-69.1; OR=NC, CI95%= NC, respectively. We did not find statistically significant differences between IDO levels in severe dengue and uncomplicated dengue (p=1.000, OR=1.0, CI95%= 0.2-6.1).Conclusions:
In the early phase of the dengue infection (96 hours), ST2, TRAIL and TNF a quantifications could contribute to the prediction of complications of the illness.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Facteur de nécrose tumorale alpha
/
Récepteurs de surface cellulaire
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Dengue sévère
/
Ligand TRAIL
Type d'étude:
Essai clinique contrôlé
/
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
/
Étude de dépistage
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Biomédica (Bogotá)
Thème du journal:
Médicament
Année:
2013
Type:
Article
Pays d'affiliation:
Colombie
Institution/Pays d'affiliation:
Universidad Industrial de Santander/CO
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