Role of Notch signaling in the mammalian heart
Braz. j. med. biol. res
;
47(1): 1-10, 01/2014. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-697677
ABSTRACT
Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical in mammalian cardiogenesis, as mutations in this signaling pathway are linked to human congenital heart disease. Furthermore, Notch signaling can repair myocardial injury by promoting myocardial regeneration, protecting ischemic myocardium, inducing angiogenesis, and negatively regulating cardiac fibroblast-myofibroblast transformation. This review provides an update on the known roles of Notch signaling in the mammalian heart. The goal is to assist in developing strategies to influence Notch signaling and optimize myocardial injury repair.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Transduction du signal
/
Récepteurs Notch
/
Cardiopathies
/
Myocarde
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2014
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Chine
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