Morphologic features frommdxmice spleens, used for duchenne muscular dystrophy studies
Braz. j. morphol. sci
;
30(1): 21-27, 2013. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-699326
ABSTRACT
The mdx mice model is widely used for Duchenne muscular dystrophy (DMD) studies, which is present in a high percentage from newborns human males. Therefore, the aim of this study was to evaluate possible morphological changes from spleens in these mice and to compare with normal mice (Mus musculus) in contribution to DMD understanding and its consequences on immune system by affected individuals. The study was performed by light and scanning electron microscopy (SEM) techniques beyond immunohistochemistry. Was found microscopically an increased number of lymph nodes and decreased in red pulp region by mdx, beyond a larger VEGF-C (vascular endothelial growth factor C) expression stimulates lymphangiogenesis in red pulp region from spleen. These findings suggest a spleen adaptation in order to supply immunological demand due upper respiratory infection, which are common in individuals affected by Duchenne muscular dystrophy.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Infections de l'appareil respiratoire
/
Lymphocytes
/
Myopathie de Duchenne
/
Facteur de croissance endothéliale vasculaire de type A
/
Système immunitaire
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. morphol. sci
Thème du journal:
Anatomie
Année:
2013
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
São Paulo University/BR
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