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Are leprosy reactions autoinflammatory diseases?
Quandelacy, Talia; Holtz, Meredith; Franco-Paredes, Carlos.
  • Quandelacy, Talia; Emory University School of Medicine. Department of Medicine. Division of Infectious Diseases. Atlanta. US
  • Holtz, Meredith; Emory University School of Medicine. Department of Medicine. Division of Infectious Diseases. Atlanta. US
  • Franco-Paredes, Carlos; Emory University School of Medicine. Department of Medicine. Division of Infectious Diseases. Atlanta. US
Bol. méd. Hosp. Infant. Méx ; 68(2): 127-129, mar.-abr. 2011.
Article Dans Anglais | LILACS | ID: lil-700903
ABSTRACT
There are two types of leprosy reactions reversal reactions or type 1 and erythema nodosum leprosum or type 2. Deformity and disability associated with leprosy are frequently the result of uncontrolled or untreated reactions. Although there is current availability of glucocorticoids as the mainstay of therapy, much needs to be learned about the etiology, risk factors, and pathogenesis of leprosy reactions. There is some evidence that leprosy reactions may represent, particularly, erythema nodosum leprosum autoinflammatory disease due to the aberrant activation of the innate immune system. The role for herpesviruses influencing autophagy in macrophages needs to be evaluated in the pathogenesis of leprosy reactions.

Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Facteurs de risque langue: Anglais Texte intégral: Bol. méd. Hosp. Infant. Méx Thème du journal: Pédiatrie Année: 2011 Type: Article Pays d'affiliation: États-Unis d'Amérique Institution/Pays d'affiliation: Emory University School of Medicine/US

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Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Facteurs de risque langue: Anglais Texte intégral: Bol. méd. Hosp. Infant. Méx Thème du journal: Pédiatrie Année: 2011 Type: Article Pays d'affiliation: États-Unis d'Amérique Institution/Pays d'affiliation: Emory University School of Medicine/US