Trombosis venosa portal e hiperplasia nodular regenerativa hepática; posible efecto adverso asociado a bevacizumab y oxaliplatino / Portal vein thrombosis and nodular regenerative hyperplasia associated with the use of bevacizumab and oxaliplatin. Report of one case
Rev. méd. Chile
;
141(10): 1344-1348, oct. 2013. ilus
Article
Dans Espagnol
| LILACS
| ID: lil-701746
ABSTRACT
Nodular regenerative hyperplasia (NRH) consists in diffuse transformation of the hepatic parenchyma into small regenerative nodules without fibrosis, secondary to vascular occlusion and flow alterations. This gives a nodular appearance to theliver, as there is atrophy and compensatory hypertrophy of hepatocytes. We reporta 69-year-old male who suffered of colon cancer and was treated with Oxaliplatin (OX) and Bevacizumab (B). During treatment with B the patient presented a partial thrombosis of the portal vein, that one year later became permeable. Esophageal varices were found in an upper digestive endoscopy. Hepatic tests were normal. Aliver biopsy was performed and informed nodular regenerative hyperplasia. Thus, the different factors that could explain this pathology are analyzed. B, a monoclonal antibody against vascular endothelial growth factor, reduces the anti-apoptotic, anti-inflammatory and survival effects produced by this factor, affecting the vascular protection of the endothelial cell. On the other hand, OX activates metalloproteinasesand depletes sinusoidal glutathione producing sinusoidal lesions. Thus, (OX) would be associated with sinusoidal obstruction and NRH sporadically. It is important to discuss the possible etiologic factors that can cause NRH reviewing the hepatotoxic effects caused by both drugs.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Composés organiques du platine
/
Veine porte
/
Thrombose veineuse
/
Hyperplasie focale nodulaire
/
Anticorps monoclonaux humanisés
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2013
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Universidad de los Andes/CL
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