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Leprosy and hepatitis B coinfection in southern Brazil
Leitao, Cleverson; Ueda, Denis; Braga, Anna Carolina de Moraes; Boldt, Angelica B.W.; Messias-Reason, Iara J.T..
  • Leitao, Cleverson; Federal University of Parana. Hospital de Clinicas. Department of Medical Pathology. Laboratorio de Imunopatologia Molecular. Curitiba. BR
  • Ueda, Denis; Federal University of Parana. Hospital de Clinicas. Department of Medical Pathology. Laboratorio de Imunopatologia Molecular. Curitiba. BR
  • Braga, Anna Carolina de Moraes; Federal University of Parana. Hospital de Clinicas. Department of Medical Pathology. Laboratorio de Imunopatologia Molecular. Curitiba. BR
  • Boldt, Angelica B.W.; Federal University of Parana. Hospital de Clinicas. Department of Medical Pathology. Laboratorio de Imunopatologia Molecular. Curitiba. BR
  • Messias-Reason, Iara J.T.; Federal University of Parana. Hospital de Clinicas. Department of Medical Pathology. Laboratorio de Imunopatologia Molecular. Curitiba. BR
Braz. j. infect. dis ; 18(1): 8-12, Jan-Feb/2014. tab
Article Dans Anglais | LILACS | ID: lil-703058
ABSTRACT
To investigate the association of leprosy with hepatitis B virus (HBV) infection, as yet unknown for South Brazil, we assessed hepatitis B virus coinfection in 199 South Brazilian leprosy patients (119 lepromatous, 15 tuberculoid, 30 borderline, 12 undetermined and 23 unspecified) and in 681 matched blood donors by screening for the hepatitis B virus markers HBSAg and anti-HBc, using ELISA. Positive samples were retested and anti-HBc+ only samples were tested for the hepatitis B surface antibody (anti-HBs). There was a strong association between leprosy and hepatitis B virus infection (OR = 9.8, 95% CI = 6.4–14.7; p = 0.004·E−30), as well as an association between HBV infection and lepromatous leprosy, compared to other forms (OR = 2.4, 95% CI = 1.2–4.8; p = 0.017). We also found that confinement due to leprosy was associated with hepatitis B virus infection (OR = 3.9, 95% CI = 2.1–7.4; p = 0.015·E−3). Leprosy patients are susceptible to develop hepatitis B virus infection, especially lepromatous. Institutionalized patients, who probably present a stronger Th2 response, have higher risk of being exposed to hepatitis B virus. This clearly emphasizes the need for special care to leprosy patients in preventing hepatitis B virus coinfection in South Brazil.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Virus de l'hépatite B / Co-infection / Hépatite B / Lèpre Type d'étude: Etude diagnostique Limites du sujet: Adolescent / Adulte / Femelle / Humains / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Braz. j. infect. dis Thème du journal: Maladies transmissibles Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Federal University of Parana/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Virus de l'hépatite B / Co-infection / Hépatite B / Lèpre Type d'étude: Etude diagnostique Limites du sujet: Adolescent / Adulte / Femelle / Humains / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Braz. j. infect. dis Thème du journal: Maladies transmissibles Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Federal University of Parana/BR