In vitro antimalarial activity of tigecycline against Plasmodium falciparum culture-adapted reference strains and clinical isolates from the Brazilian Amazon
Rev. Soc. Bras. Med. Trop
;
47(1): 110-112, Jan-Feb/2014. tab
Article
Dans Anglais
| LILACS
| ID: lil-703166
ABSTRACT
Introduction:
We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria.Methods:
A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate antimalarial activity.Results:
The geometric-mean 50% effective concentration (EC50%) of tigecycline was 535.5 nM (confidence interval (CI) 344.3-726.8). No significant correlation was found between the EC50% of tigecycline and that of any other tested antimalarial drug.Conclusions:
Tigecycline may represent an alternative drug for the treatment of patients with severe malaria. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Plasmodium falciparum
/
Protéines
/
Minocycline
/
Antipaludiques
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Mato Grosso/BR
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