Your browser doesn't support javascript.
loading
Parasite load and risk factors for poor outcome among children with visceral leishmaniasis. A cohort study in Belo Horizonte, Brazil, 2010-2011
Mourão, Maria Vitória Assumpção; Toledo Jr, Antonio; Gomes, Luciana Inácia; Freire, Verônica Vieira; Rabello, Ana.
Affiliation
  • Mourão, Maria Vitória Assumpção; Fundação Hospitalar do Estado de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte. BR
  • Toledo Jr, Antonio; Fundação Hospitalar do Estado de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte. BR
  • Gomes, Luciana Inácia; Fundação Hospitalar do Estado de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte. BR
  • Freire, Verônica Vieira; Fundação Hospitalar do Estado de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte. BR
  • Rabello, Ana; Fundação Hospitalar do Estado de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte. BR
Mem. Inst. Oswaldo Cruz ; 109(2): 147-153, abr. 2014. tab, graf
Article de En | LILACS | ID: lil-705816
Bibliothèque responsable: BR1.1
ABSTRACT
Clinical and laboratory risk factors for death from visceral leishmaniasis (VL) are relatively known, but quantitative real-time polymerase chain reaction (qPCR) might assess the role of parasite load in determining clinical outcome. The aim of this study was to identify risk factors, including parasite load in peripheral blood, for VL poor outcome among children. This prospective cohort study evaluated children aged ≤ 12 years old with VL diagnosis at three times pre-treatment (T0), during treatment (T1) and post-treatment (T2). Forty-eight patients were included and 16 (33.3%) met the criteria for poor outcome. Age ≤ 12 months [relative risk (RR) 3.51; 95% confidence interval (CI) 1.89-6.52], tachydyspnoea (RR 3.46; 95% CI 2.19-5.47), bacterial infection (RR 3.08; 95% CI 1.27-7.48), liver enlargement (RR 3.00; 95% CI 1.44-6.23) and low serum albumin (RR 7.00; 95% CI 1.80-27.24) were identified as risk factors. qPCR was positive in all patients at T0 and the parasite DNA was undetectable in 76.1% of them at T1 and in 90.7% at T2. There was no statistical association between parasite load at T0 and poor outcome.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: 29918 / Charge parasitaire / Leishmania / Leishmaniose viscérale Type d'étude: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies Limites du sujet: Child / Child, preschool / Female / Humans / Male Pays comme sujet: America do sul / Brasil langue: En Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: MEDICINA TROPICAL / PARASITOLOGIA Année: 2014 Type: Article / Project document

Texte intégral: 1 Indice: LILACS Sujet Principal: 29918 / Charge parasitaire / Leishmania / Leishmaniose viscérale Type d'étude: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies Limites du sujet: Child / Child, preschool / Female / Humans / Male Pays comme sujet: America do sul / Brasil langue: En Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: MEDICINA TROPICAL / PARASITOLOGIA Année: 2014 Type: Article / Project document