Influence of zearalenone on some metabolic pathways of the rat liver

ABSTRACT

Zearali, a natural product isolated from Fusarium granunearum, has anabolic properties and effects glycogen catabolism in the rat liver. In the isolated perfused liver, L-lactate production, glucose release from endogenous glycogen and oxygen uptake are increased upon infusion of the compound. Fructose metabolism is only slightly affected by zearalenone, except for the transformation of fructose intoglucose which is decreased. The actiohn of zearalenone seems to be related to the amount of drug retained by the liver rather than to the concentration in the perfusion fluid