Participation of tumor necrosis factor in the antitumor activity of mycobacterial trehalose dimycolate (cord factor)
Braz. j. med. biol. res
;
22(3): 341-4, 1989. ilus
Article
Dans Anglais
| LILACS
| ID: lil-70688
RESUMO
Trehalose dimycolate, a mycobacterial glycolipid also known as cord factor, retains some of the antitumor properties of the intact BCG. Murine macrophages incubated in vitro in the presence of trehalose dimycolate for 20 h at 37-C released a factor which was cytotoxic for the L929 tumor cell line. Anti-tumor necrosis factor (TNF) blocked the cytotoxicity of trehalose dimycolate macrophage supernatant. Therefore the antitumor activity of trehalose dimycolate can be attributed to TNF released in the in vitro assay
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Indice:
LILAS (Amériques)
Sujet Principal:
Facteurs cord
/
Macrophages
/
Antigènes néoplasiques
/
Cellules tumorales circulantes
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1989
Type:
Article
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