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Bullous pemphigoid and comorbidities: a case-control study in Portuguese patients
Teixeira, Vera Barreto; Cabral, Rita; Brites, Maria Manuel; Vieira, Ricardo; Figueiredo, Américo.
  • Teixeira, Vera Barreto; Coimbra University Hospital. PT
  • Cabral, Rita; Coimbra University Hospital. PT
  • Brites, Maria Manuel; Coimbra University Hospital. PT
  • Vieira, Ricardo; Coimbra University Hospital. PT
  • Figueiredo, Américo; Coimbra University Hospital. PT
An. bras. dermatol ; 89(2): 274-278, Mar-Apr/2014. tab, graf
Article Dans Anglais | LILACS | ID: lil-706965
ABSTRACT

BACKGROUND:

aAlthough rare, bullous pemphigoid (BP) is the most common autoimmune blistering disease. Recent studies have shown that patients with bullous pemphigoid are more likely to have neurological and psychiatric diseases, particularly prior to the diagnosis of bullous pemphigoid.

OBJECTIVE:

The aims were (i) to evaluate the demographic and clinical features of bullous pemphigoid from a database of patients at a Portuguese university hospital and (ii) to compare the prevalence of comorbid conditions before the diagnosis of bullous pemphigoid with a control group.

METHODS:

Seventy-seven patients with bullous pemphigoid were enrolled in the study. They were compared with 176 age- and gender-matched controls, which also had the same inpatient to outpatient ratio, but no history of bullous or cutaneous malignant disease. Univariate and multivariate analyses were used to calculate odds ratios for specific comorbid diseases.

RESULTS:

At least one neurologic diagnosis was present in 55.8% of BP patients compared with 20.5% controls (p<0.001). Comparing cases to controls, stroke was seen in 35.1 vs. 6.8%, OR 8.10 (3.80-17.25); dementia in 37.7 vs. 11.9%, OR 5.25 (2.71-10.16); and Parkinson's disease in 5.2 vs. 1.1%, OR 4.91 (0.88-27.44). Using multivariate analysis, all diseases except Parkinson's retained their association with BP. Patients under systemic treatment were eight times more likely to have complications than those treated with topical steroids (p< 0.017).

CONCLUSIONS:

The results of this study substantiate the association between BP and neurological diseases. In addition, they highlight the potential complications associated with the treatment of BP. .
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Maladies du système nerveux central / Pemphigoïde bulleuse Type d'étude: Études d'évaluation / Étude observationnelle / Étude de prévalence / Étude pronostique / Facteurs de risque Limites du sujet: Adulte très âgé / Aged80 / Femelle / Humains / Mâle Pays comme sujet: Europe langue: Anglais Texte intégral: An. bras. dermatol Thème du journal: Dermatologie Année: 2014 Type: Article Pays d'affiliation: Portugal Institution/Pays d'affiliation: Coimbra University Hospital/PT

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Maladies du système nerveux central / Pemphigoïde bulleuse Type d'étude: Études d'évaluation / Étude observationnelle / Étude de prévalence / Étude pronostique / Facteurs de risque Limites du sujet: Adulte très âgé / Aged80 / Femelle / Humains / Mâle Pays comme sujet: Europe langue: Anglais Texte intégral: An. bras. dermatol Thème du journal: Dermatologie Année: 2014 Type: Article Pays d'affiliation: Portugal Institution/Pays d'affiliation: Coimbra University Hospital/PT