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An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation
Migliavacca, Raphaella de Oliveira; Piltcher, Otávio Bejzman; Kliemann, Lúcia Maria; Cerski, Marcelle Reesink; Meyer, Fabíola; Oppermann, Paula de Oliveira; Machado Filho, Geraldo; Kang, Suzie Hyeona; Costa, Sady Selaimen da.
  • Migliavacca, Raphaella de Oliveira; Rio Grande do Sul Federal University. BR
  • Piltcher, Otávio Bejzman; Rio Grande do Sul Federal University. BR
  • Kliemann, Lúcia Maria; Rio Grande do Sul Federal University. BR
  • Cerski, Marcelle Reesink; Rio Grande do Sul Federal University. BR
  • Meyer, Fabíola; Rio Grande do Sul Federal University. BR
  • Oppermann, Paula de Oliveira; Rio Grande do Sul Federal University. BR
  • Machado Filho, Geraldo; Rio Grande do Sul Federal University. BR
  • Kang, Suzie Hyeona; Rio Grande do Sul Federal University. BR
  • Costa, Sady Selaimen da; Rio Grande do Sul Federal University. BR
Acta cir. bras ; 29(5): 313-319, 05/2014. tab, graf
Article Dans Anglais | LILACS | ID: lil-709233
ABSTRACT

PURPOSE:

Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits.

METHODS:

In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa.

RESULTS:

Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026).

CONCLUSION:

It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies. .
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Sinusite / Rhinite / Modèles animaux de maladie humaine / Sinus maxillaire / Fosse nasale Type d'étude: Etude d'étiologie / Études d'évaluation / Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Rio Grande do Sul Federal University/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Sinusite / Rhinite / Modèles animaux de maladie humaine / Sinus maxillaire / Fosse nasale Type d'étude: Etude d'étiologie / Études d'évaluation / Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Rio Grande do Sul Federal University/BR