Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
36(2): 156-167, may. 13, 2014. graf
Article
Dans Anglais
| LILACS
| ID: lil-710208
ABSTRACT
Introduction:
Mitochondrial dysfunction has been postulated to participate in the development of many neuropsychiatric disorders, but there is no consensus as to its role. The aim of this paper is to review recent studies and to outline the current understanding of the association between mitochondrial dysfunction and psychiatric disorders.Methodology:
We reviewed articles that evaluated mitochondrial dysfunction and psychiatric disorders, with a particular focus on depression, bipolar disorder, anxiety disorders, obsessive-compulsive disorder, and autism spectrum disorder, and the association between mitochondrial dysfunction and development of these disorders.Results:
Evidence suggests that alterations in mitochondrial morphology, brain energy metabolism, and mitochondrial enzyme activity may be involved in the pathophysiology of different neuropsychiatric disorders, given their key role in energy metabolism in the cell.Conclusions:
Understanding the interactions between mitochondrial dysfunction and development of psychiatric disorders may help establish more effective therapeutic strategies for these disorders and thus lead to better outcomes for affected subjects. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Système nerveux central
/
Maladies mitochondriales
/
Troubles mentaux
/
Mitochondries
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Thème du journal:
Psychiatrie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade do Extremo Sul Catarinense (UNESC)/BR
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