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Morphological changes in the liver and kidneys of rats subjected to terminal ileum exclusion during obstructive cholestasis
Costa, Evandro Luis de Oliveira; Azevedo Jr, Geraldo Magela de; Petroianu, Andy.
  • Costa, Evandro Luis de Oliveira; Minas Gerais Federal University. Faculty of Medicine. Department of Surgery. Belo Horizonte. BR
  • Azevedo Jr, Geraldo Magela de; Minas Gerais Federal University. Faculty of Medicine. Department of Surgery. Belo Horizonte. BR
  • Petroianu, Andy; Minas Gerais Federal University. Faculty of Medicine. Department of Surgery. Belo Horizonte. BR
Acta cir. bras ; 29(6): 353-358, 06/2014. tab, graf
Article Dans Anglais | LILACS | ID: lil-711597
ABSTRACT

PURPOSE:

To investigate the effects of ileal exclusion on hepatic and renal morphology in extra-hepatic cholestasis.

METHODS:

Twenty four rats were distributed into three groups. Group 1 (control) underwent laparotomy and laparorrhaphy. The animals in groups 2 and 3 underwent hepatic duct ligature and kept in cholestasis for four weeks. After this period, the rats in groups 2 and 3 underwent internal biliary derivation. In Group 3, the last ten centimeters of the terminal ileum were by passed and excluded. Four weeks later, histological and biochemical analysis were performed in all animals of the three groups.

RESULTS:

In Group 1, no abnormalities regarding hepatic morphology were observed. All animals from groups 2 and 3 presented hepatic fibrosis. No difference was observed between the two groups. No morphological differences in renal histology could be identified among the three groups. There were differences in AST (p<0.05), ALT (p<0.05), direct bilirubin (p<0.05), ƔGT (p<0.05), urea (p<0.05) and creatinine (p<0.05) in Group 3 compared to control.

CONCLUSION:

The distal ileum exclusion had no influence upon the hepatic and renal morphological alterations, and biochemical liver and kidney tests have worsened. .
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Cholestase extrahépatique / Iléum / Rein / Foie Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Minas Gerais Federal University/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Cholestase extrahépatique / Iléum / Rein / Foie Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Minas Gerais Federal University/BR