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The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
Steglich, Raquel Bissacotti; Meneghello, Luana Pizarro; Carvalho, André Vicente Esteves de; Cheinquer, Hugo; Muller, Fernanda Melo; Reginatto, Flávia Pereira.
Affiliation
  • Steglich, Raquel Bissacotti; Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre. Porto Alegre. BR
  • Meneghello, Luana Pizarro; Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre. Porto Alegre. BR
  • Carvalho, André Vicente Esteves de; Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre. Porto Alegre. BR
  • Cheinquer, Hugo; Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre. Porto Alegre. BR
  • Muller, Fernanda Melo; Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre. Porto Alegre. BR
  • Reginatto, Flávia Pereira; Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre. Porto Alegre. BR
An. bras. dermatol ; An. bras. dermatol;89(4): 652-654, Jul-Aug/2014. graf
Article de En | LILACS | ID: lil-715540
Bibliothèque responsable: BR1.1
ABSTRACT
Psoriasis is a chronic inflammatory, immune-mediated disease that affects 1% to 2% of the world's population. Immunobiological medications are prescribed for certain patients with severe forms of psoriasis, however, these drugs increase the risk of reactivation of viral diseases such as hepatitis B. We report the case of a patient with severe psoriasis with positive serology for the Hepatitis B virus, who received ustekinumab (a human monoclonal antibody against interleukin 12 and 23). In this patient, the use of ustekinumab did not reactivate the Hepatitis B virus. Given the high prevalence of chronic viral infections in patients who are candidates for biologic therapy, as well as the potential for reactivate chronic viral illness, randomized controlled studies are needed to assess the risks and benefits of such therapy in these populations.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Psoriasis / Virus de l'hépatite B / Anticorps monoclonaux humanisés / Hépatite B Type d'étude: Clinical_trials / Risk_factors_studies Limites du sujet: Humans / Male langue: En Texte intégral: An. bras. dermatol Thème du journal: DERMATOLOGIA Année: 2014 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Psoriasis / Virus de l'hépatite B / Anticorps monoclonaux humanisés / Hépatite B Type d'étude: Clinical_trials / Risk_factors_studies Limites du sujet: Humans / Male langue: En Texte intégral: An. bras. dermatol Thème du journal: DERMATOLOGIA Année: 2014 Type: Article