Inferences about the global scenario of human T-cell lymphotropic virus type 1 infection using data mining of viral sequences
Mem. Inst. Oswaldo Cruz
;
109(4): 448-451, 03/07/2014. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-716298
ABSTRACT
Human T-cell lymphotropic virus type 1 (HTLV-1) is mainly associated with two diseases tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) and adult T-cell leukaemia/lymphoma. This retrovirus infects five-10 million individuals throughout the world. Previously, we developed a database that annotates sequence data from GenBank and the present study aimed to describe the clinical, molecular and epidemiological scenarios of HTLV-1 infection through the stored sequences in this database. A total of 2,545 registered complete and partial sequences of HTLV-1 were collected and 1,967 (77.3%) of those sequences represented unique isolates. Among these isolates, 93% contained geographic origin information and only 39% were related to any clinical status. A total of 1,091 sequences contained information about the geographic origin and viral subtype and 93% of these sequences were identified as subtype “a”. Ethnicity data are very scarce. Regarding clinical status data, 29% of the sequences were generated from TSP/HAM and 67.8% from healthy carrier individuals. Although the data mining enabled some inferences about specific aspects of HTLV-1 infection to be made, due to the relative scarcity of data of available sequences, it was not possible to delineate a global scenario of HTLV-1 infection.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Virus T-lymphotrope humain de type 1
/
Infections à HTLV-I
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Centro de Pesquisa Gonçalo Moniz-Fiocru/BR
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