Outstanding insecurities concerning the use of an Ov16-based ELISA in the Amazonia onchocerciasis focus
Mem. Inst. Oswaldo Cruz
;
109(4): 506-508, 03/07/2014.
Article
Dans Anglais
| LILACS
| ID: lil-716302
ABSTRACT
In a recent issue of Memórias do Instituto Oswaldo Cruz, published in Rio de Janeiro in February 2014 (109 87-92), Adami et al. have published a survey reporting Mansonella parasite prevalence in the Amazon Region. This report makes a useful contribution to the existing knowledge of filarial parasite distribution within the Amazon area, parasite prevalence rates in relation to age and occupation and provides observations on the possible clinical impact of Mansonella ozzardi. Their publication also provides an account of what appears to be a novel ELISA that has recently been used in the Simuliidae and Onchocerciasis Laboratory of the Oswaldo Cruz Institute, Rio de Janeiro, Brazil. We are concerned that the publication of this ELISA may have created an excessively positive impression of the effectiveness of the onchocerciasis recrudescence serological surveillance tools that are presently available for use in the Amazonia onchocerciasis focus. In this letter we have, thus, sought to highlight some of the limitations of this ELISA and suggest how continuing insecurities concerning the detection of antibodies to Onchocerca volvulus within the Amazonia onchocerciasis focus might be minimised.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Onchocercose
/
Protéines de transport
/
Protéines d'helminthes
/
Onchocerca volvulus
Type d'étude:
Facteurs de risque
Limites du sujet:
Animaux
/
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Instituto Leônidas e Maria Deane-Fiocruz/BR
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