In vivo assessment of antiretroviral therapy-associated side effects
Mem. Inst. Oswaldo Cruz
;
109(4): 484-487, 03/07/2014. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-716314
ABSTRACT
Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart. These results suggest that hamsters are an interesting model for the study of the side effects of antiretroviral drugs, such as PIs.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Matières grasses alimentaires
/
Inhibiteurs de protéase du VIH
/
Indinavir
Type d'étude:
Facteurs de risque
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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