Neonatal lipopolysaccharide exposure induces sexually dimorphic sickness behavior in adult rats
Psychol. neurosci. (Impr.)
;
7(2): 113-123, Jan.-June 2014. ilus, graf
Article
Dans Anglais
| LILACS
| ID: lil-718331
ABSTRACT
The aim of the present study was to evaluate whether neonatal exposure to lipopolysaccharide (LPS; 50 µg/kg, i.p., on postnatal day 2) induces depressive- and/or anxiety-like effects and sexually dimorphic responses in rats challenged with LPS (100 µg/kg, i.p.) in adulthood. The results revealed that males presented a less depressive state in the forced swim test and exhibited no changes in general motor activity in the open field test. Females exhibited an increase in sickness behavior, revealing different behavioral strategies in response to a bacterial disease. The male rats also exhibited higher cell proliferation, reflected by bone marrow and peripheral blood counts, and female rats exhibited a decrease in corticosterone levels. No changes were observed in the elevated plus maze or peripheral cytokine levels (interleukin-1β and tumor necrosis factor-α). Neonatal exposure to LPS induced sexually dimorphic behavioral, neuroendocrine, and immune effects after an LPS challenge in adulthood, differentially affecting male and female susceptibility to disease later in life...
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Lipopolysaccharides
/
Caractères sexuels
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Psychol. neurosci. (Impr.)
Thème du journal:
Neurologie
/
Psychologie
Année:
2014
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Paulista/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS