Acute schistosomiasis mansoni: the pathophysiological cycle of the schistosoma mansoni and the granulomas as egg of columbus / Esquistossomose mansônica aguda: o ciclo fisiopatológico do Schistosoma mansoni e o granuloma como ovo de colombo*
RBM rev. bras. med
;
71(4)abr. 2014.
Article
Dans Portugais
| LILACS
| ID: lil-721594
ABSTRACT
Background and objectives:
Schistosomiasis has a wide geographical distribution, and is found in many countries including Brazil, where it is endemic in some states. This study aimed to describe the main pathogenic aspects of the Homo sapiens sapiens / Shistosoma mansoni interaction, focusing on the acute phase of illness. Accordingly, we reviewed the literature using a with a defined search strategy, using PubMed. The selected papers were read and the information organized into two sections, focusing on (1) the pathophysiological human-helminth interaction "cycle" and (2) the role of granuloma in the disease. Content The pathologic process begins with the penetration of the cercariae into the skin, from which point the response mechanisms to infection are triggered - linked to the biological cycle of the helminth in the human body - and justifying the development of acute and chronic forms of the disease. The acute phase is characterized by the formation of necrotic-exudative granulomas around the eggs. Continuous oviposition allows for modulation of the immune response, the histopathological significance of which is the disappearance of the necrotic areas and size reduction of the granulomas surrounding the eggs.Conclusion:
An understanding of the Homo sapiens sapiens/Schistosoma mansoni interaction is essential in order to think of ways to intervene with the natural history of the disease, avoiding the emergence of severe forms - especially in the context of evolution to chronic disease -, and, perhaps, corroborating for a better coexistence between man and helminth, in the best spirit of cohabitology...
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Indice:
LILAS (Amériques)
Sujet Principal:
Anatomopathologie
/
Schistosomiase à Schistosoma mansoni
Limites du sujet:
Humains
langue:
Portugais
Texte intégral:
RBM rev. bras. med
Thème du journal:
Médicament
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Centro Universitário Serra dos Órgãos/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade Federal de Viçosa/BR
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