Oral bacillus Calmette-Guérin vaccine against tuberculosis: why not?
Mem. Inst. Oswaldo Cruz
;
109(6): 838-845, 09/09/2014.
Article
Dans Anglais
| LILACS
| ID: lil-723988
ABSTRACT
The bacillus Calmette-Guérin (BCG) vaccine is the only licensed vaccine for human use against tuberculosis (TB). Although controversy exists about its efficacy, the BCG vaccine is able to protect newborns and children against disseminated forms of TB, but fails to protect adults against active forms of TB. In the last few years, interest in the mucosal delivery route for the vaccine has been increasing owing to its increased capacity to induce protective immune responses both in the mucosal and the systemic immune compartments. Here, we show the importance of this route of vaccination in newly developed vaccines, especially for vaccines against TB.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tuberculose pulmonaire
/
Vaccin BCG
/
Vaccination
Limites du sujet:
Adolescent
/
Adulte
/
Enfant
/
Humains
/
Nouveau-né
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Instituto Oswaldo Cruz/BR
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