Molecular cloning of a hyaluronidase from Bothrops pauloensis venom gland
J. venom. anim. toxins incl. trop. dis
;
2004/02/2014.
Article
Dans Anglais
| LILACS
| ID: lil-724687
ABSTRACT
Hyaluronate is one of the major components of extracellular matrix from vertebrates whose breakdown is catalyzed by the enzyme hyaluronidase. These enzymes are widely described in snake venoms, in which they facilitate the spreading of the main toxins in the victims body during the envenoming. Snake venoms also present some variants (hyaluronidases-like substances) that are probably originated by alternative splicing, even though their relevance in envenomation is still under investigation. Hyaluronidases-like proteins have not yet been purified from any snake venom, but the cDNA that encodes these toxins was already identified in snake venom glands by transcriptomic analysis. Herein, we report the cloning and in silico analysis of the first hyaluronidase-like proteins from a Brazilian snake venom.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Venins de vipère
/
Clonage moléculaire
/
Hyaluronoglucosaminidase
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Thème du journal:
Toxicologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Uberlândia/BR
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