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The effect of sulphasalazine on the in vitro activation of human peripheral blood mononuclear cells by phytohemagglutinin P
Braz. j. med. biol. res ; 22(4): 513-6, 1989. tab
Article Dans Anglais | LILACS | ID: lil-72500
ABSTRACT
The in vitro action of sulphaslazine, BW 755-C and indomethacin on phytohemaglutinin P-induced human peripheral brood mononuclear cell activation was studied. Sulphasalazine increased, while indomethacin and BW 755-C decreased, prostaglandin E2 (PGE2) accumulation in activated cultures. When used together with indomethacin or BW 755-C, sulpjasalazine did not counteract the inhibiton of PGE2 caused by the other two. Sulphasalazine inhibited phytohemagglutinin P-induced cell activation in a concentration-dependent manner even when used together with indomethacin or BW 755-C. BW 755-C inhibited cell activation at 350 micronM, wehreas at 11, whereas at 11 micronM only increased sulphasalazine-induced inhibition. The implications of these findings on the etiopathology of inflammatory bowel disease are discussed
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Indice: LILAS (Amériques) Sujet Principal: Phytohémagglutinine / Sulfasalazine / Techniques in vitro / Monocytes / Maladies inflammatoires intestinales / Indométacine Limites du sujet: Humains langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 1989 Type: Article

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Indice: LILAS (Amériques) Sujet Principal: Phytohémagglutinine / Sulfasalazine / Techniques in vitro / Monocytes / Maladies inflammatoires intestinales / Indométacine Limites du sujet: Humains langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 1989 Type: Article