Non-Hodgkins Lymphoma: Five-year Survival in a Historical Cohort of Patients who Underwent Stem Cell Transplantationin Brazil / Linfoma No-Hodgkin: Supervivencia de Cinco Años en una Cohorte Histórica dePacientes Sometidos a Trasplante de Células Madre en Brasil / Linfoma Não-Hodgkin: Sobrevida de Cinco Anos em uma Coorte Histórica dePacientes Submetidos a Transplante de Células-Tronco no Brasil
Rev. bras. cancerol
;
60(1): 35-42, jan.-mar. 2014. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-726080
ABSTRACT
Introduction:
Several studies have shown the benefits of stem cell transplantation in the treatment of Non-Hodgkins lymphoma.Objective:
To evaluate survival and associated factors in transplanted Non-Hodgkins lymphoma patients in Brazil.Method:
We conducted a retrospective analysis of 100 adult patients with Non-Hodgkins lymphoma transplanted in a national reference center for hematopoietic stem cell transplantation between 1997 and 2009. Data was obtained from medical charts and included besides socio-demographic and lifestyle variables, others relatedto diagnosis and transplantation. The five-year survival probability was estimated using the Kaplan-Meier method and differences between curves were tested with the log-rank test, assuming statistical significance level of 5%. Cox regression was performed for multivariate analysis.Results:
Median age at diagnosis was 43 years (17-65) and 45 years (18-66) at transplantation. Median time between diagnosis and transplantation was 17 months (4-173). The probability of survival at 5 years was 50.8% with a median survival time of 22.5 months. In multivariate analysis, evidence of disease 12 months after transplant (HR 4.49; 95% CI 2.15-9.39), chemo-sensitivity to the last regimenbefore transplant (HR 2.92; 95% CI 1.35-6.32) and advanced stage at diagnosis (HR 1.96, 95% CI 1.02-3.80)were prognostic factors for survival.Conclusion:
Median age at transplantation in this cohort was similar to that of other studies but median time between diagnosis and transplantation was higher. Although overall survival (5 years) approached that reported in other studies, different treatment protocols and specific characteristics of each populationlimit comparisons
Analise de Sobrevida; Analísis de Supervivencia; Brasil; Brasil; Instituciones Oncológicas; Instituto do Câncer; Linfoma no Hodgkin; Linfoma não Hodgkin; Tasa de Supervivencia; Taxa de Sobrevida; Transplante de Células Madre; Transplantes de Células-Tronco; hematopoietic stem cell transplantation; lymphoma, non-Hodgkin; prognostic factor; survival
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Lymphome malin non hodgkinien
/
Brésil
/
Établissements de cancérologie
/
Analyse de survie
/
Taux de survie
/
Transplantation de cellules souches
Type d'étude:
Guide de pratique
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Rev. bras. cancerol
Thème du journal:
Tumeurs
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Center for Cancer Treatment-CENTRON/BR
/
Oswaldo Cruz Foundation/BR
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