Estudio del control metabólico en pacientes diabéticos en hemodiálisis crónica: hemoglobina glicosilada, fructosamina y glicemias capilares / Study of metabolic control in diabetic patients on chronic hemodialysis: glycated hemoglobin, fructosamine and capillary glycemia
Rev. chil. endocrinol. diabetes
;
6(2): 50-54, abr. 2013. tab, graf
Article
Dans Espagnol
| LILACS
| ID: lil-726574
ABSTRACT
Background:
In conditions that may change red blood cell survival, such as hemodialysis, the accuracy of A1c glycosylated hemoglobin (HbA1c) to assess metabolic control can be hampered. Other glycosylated proteins such as fructosamine, could accomplish the role of HbA1c.Aim:
To assess if HbA1c is a good metabolic control parameter in diabetic patients on chronic hemodialysis. To compare fructosamine, HbA1c and serial capillary glucose levels in the same patients. Material andMethods:
Patients on hemodialysis three times per week were studied. Twenty one subjects with diabetes mellitus and 10 non-diabetic patients were included (70 percent were male). During a period of 14 days, fasting and post prandial capillary glucose levels were measured. Venous glucose, HbA1c and fructosamine were measured at the onset and completion of the monitoring period.Results:
Diabetic patients were older than their non-diabetic counterparts (65 and 47 years respectively, p < 0.04). In diabetic and non-diabetic patients respectively, capillary blood glucose levels were 161 +/- 22 and 104 +/- 51 mg/dl, HbA1c levels were 6.8 +/- 1.2 and 5.4 +/- 0.4 percent and fructosamine levels were 282.0 +/- 126.6 and 154.6 +/- 73 umol/L. In all patients there was a positive correlation between blood glucose, HbA1c (r = 0.78 p < 0.01) and fructosamine (r = 0.52, p 0.02). There was a positive correlation between mean capillary glucose, HbA1c (r = 0.77, p < 0.01) and fructosamine (r = 0.69, p < 0.02). Among diabetic patients, the correlation coefficients between mean capillary glucose levels, HbA1c and fructosamine levels were 0.67 (p < 0.01) and 0.51 (NS), respectively.Conclusions:
Among diabetic patients on hemodialysis fructosamine levels are not a better indicator of metabolic control than HbA1c.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Hémoglobine glyquée
/
Dialyse rénale
/
Fructosamine
/
Diabète
Type d'étude:
Etude diagnostique
/
Étude observationnelle
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. chil. endocrinol. diabetes
Thème du journal:
Endocrinologie
Année:
2013
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Hospital Clínico Universidad de Chile/CL
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