Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
Braz. j. microbiol
;
45(3): 807-812, July-Sept. 2014. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-727006
ABSTRACT
Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Thiocyanates
/
Bactéries
/
Composés allyliques
/
Champignons
/
Anti-infectieux
langue:
Anglais
Texte intégral:
Braz. j. microbiol
Thème du journal:
Microbiologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Santa Catarina/BR
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