Phototherapy promotes healing of cutaneous wounds in undernourished rats
An. bras. dermatol
;
89(6): 899-904, Nov-Dec/2014. graf
Article
Dans Anglais
| LILACS
| ID: lil-727649
ABSTRACT
BACKGROUND:
Various studies have shown that phototherapy promotes the healing of cutaneous wounds.OBJECTIVE:
To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats.METHODS:
Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups nourished sham, nourished Light Emitting Diode treated, undernourished sham and undernourished Light Emitting Diode treated. In the two treated groups, two 8-mm punch wounds made on the dorsum of each rat were irradiated three times per week with 3 J/cm2 sq cm of combined 660 and 890nm light; wounds in the other groups were not irradiated. Wounds were evaluated with digital photography and image analysis, either on day 7 or day 14, with biopsies obtained on day 14 for histological studies.RESULTS:
Undernourishment retarded the mean healing rate of the undernourished sham wounds (p < 0.01), but not the undernourished Light emission diode treated wounds, which healed significantly faster (p < 0.001) and as fast as the two nourished groups. Histological analysis showed a smaller percentage of collagen in the undernourished sham group compared with the three other groups, thus confirming our photographic image analysis data.CONCLUSION:
Phototherapy reverses the adverse healing effects of undernourishment. Similar beneficial effects may be achieved in patients with poor nutritional status. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Peau
/
Cicatrisation de plaie
/
Photothérapie de faible intensité
/
Lasers à semiconducteur
Type d'étude:
Études d'évaluation
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
An. bras. dermatol
Thème du journal:
Dermatologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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