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Changes in epidemiology of rotavirus in the Triângulo Mineiro region of Brazil: lack of two consecutive rotavirus seasons
Dulgheroff, A.C.B.; Figueiredo, E.F.; Gouvêa, V.S.; Domingues, A.L.S..
Affiliation
  • Dulgheroff, A.C.B.; Universidade Federal do Triângulo Mineiro. Disciplina de Microbiologia. Instituto de Ciências Biológicas e Naturais. Uberaba. BR
  • Figueiredo, E.F.; Universidade Federal do Triângulo Mineiro. Disciplina de Microbiologia. Instituto de Ciências Biológicas e Naturais. Uberaba. BR
  • Gouvêa, V.S.; Universidade Federal do Triângulo Mineiro. Disciplina de Microbiologia. Instituto de Ciências Biológicas e Naturais. Uberaba. BR
  • Domingues, A.L.S.; Universidade Federal do Triângulo Mineiro. Disciplina de Microbiologia. Instituto de Ciências Biológicas e Naturais. Uberaba. BR
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;47(12): 1091-1095, 12/2014. tab
Article de En | LILACS | ID: lil-727660
Bibliothèque responsable: BR1.1
ABSTRACT
Rotaviruses are the main cause of infantile acute diarrhea, and a monovalent (G1P[8]) vaccine against the virus was introduced into the Brazilian National Immunization Program for all infants in March 2006. The objectives of this study were to determine the rate and genotype distribution of rotavirus causing infantile diarrhea in the Triângulo Mineiro region of Brazil during 2011-2012 and to assess the impact of local vaccination. Fecal specimens were analyzed for detection and characterization of rotavirus using polyacrylamide gel electrophoresis, reverse transcription followed by polymerase chain reaction (PCR), and PCR-genotyping assays. Overall, rotavirus was diagnosed in 1.7% (6/348) of cases. Rotavirus positivity rates decreased 88% [95% confidence intervals (CI)=15.2, 98.3%; P=0.026] in 2011 and 78% (95%CI=30.6, 93.0%; P=0.007) in 2012 when compared with available data for baseline years (2005/2006) in Uberaba. In Uberlândia, reductions of 95.3% (95%CI=66.0, 99.4%; P=0.002) in 2011, and 94.2% (95%CI=56.4, 99.2%; P=0.004) in 2012 were also observed compared with data for 2008. The circulation of rotavirus G2P[4] strains decreased during the period under study, and strains related to the P[8] genotype reemerged in the region. This study showed a marked and sustained reduction of rotavirus-related cases, with a lack of rotavirus in the 2011 and 2012 seasons, suggesting a positive impact of the vaccination program.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Infections à rotavirus / Rotavirus / Diarrhée du nourrisson Type d'étude: Screening_studies Limites du sujet: Child / Child, preschool / Humans / Infant Pays comme sujet: America do sul / Brasil langue: En Texte intégral: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Thème du journal: BIOLOGIA / MEDICINA Année: 2014 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Infections à rotavirus / Rotavirus / Diarrhée du nourrisson Type d'étude: Screening_studies Limites du sujet: Child / Child, preschool / Humans / Infant Pays comme sujet: America do sul / Brasil langue: En Texte intégral: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Thème du journal: BIOLOGIA / MEDICINA Année: 2014 Type: Article