Interferon-γ inhibits group B Streptococcus survival within human endothelial cells
Mem. Inst. Oswaldo Cruz
;
109(7): 940-943, 11/2014. graf
Article
Dans Anglais
| LILACS
| ID: lil-728811
ABSTRACT
Endothelial dysfunction is a major component of the pathophysiology of septicaemic group B Streptococcus (GBS) infections. Although cytokines have been shown to activate human umbilical vein endothelial cells (HUVECs), the capacity of interferon (IFN)-γ to enhance the microbicidal activity of HUVECs against GBS has not been studied. We report that the viability of intracellular bacteria was reduced in HUVECs activated by IFN-γ. Enhanced fusion of lysosomes with bacteria-containing vacuoles was observed by acid phosphatase and the colocalisation of Rab-5, Rab-7 and lysosomal-associated membrane protein-1 with GBS in IFN-γ-activated HUVECs. IFN-γ resulted in an enhancement of the phagosome maturation process in HUVECs, improving the capacity to control the intracellular survival of GBS.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Infections à streptocoques
/
Streptococcus agalactiae
/
Interféron gamma
/
Viabilité microbienne
/
Cellules endothéliales de la veine ombilicale humaine
/
Anti-infectieux
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal do Rio de Janeiro/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS