Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
Mem. Inst. Oswaldo Cruz
;
109(7): 972-974, 11/2014. graf
Article
Dans Anglais
| LILACS
| ID: lil-728812
ABSTRACT
There has been a resurgence in the number of pertussis cases in Brazil and around the world. Here, the genome of a clinical Bordetella pertussis strain (Bz181) that was recently isolated in Brazil is reported. Analysis of the virulence-associated genes defining the pre- and post-vaccination lineages revealed the presence of the prn2-ptxS1A-fim3B-ptxP3 allelic profile in Bz181, which is characteristic of the current pandemic lineage. A putative metallo-β-lactamase gene presenting all of the conserved zinc-binding motifs that characterise the catalytic site was identified, in addition to a multidrug efflux pump of the RND family that could confer resistance to erythromycin, which is the antibiotic of choice for treating pertussis disease.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Bordetella pertussis
/
Facteurs de virulence des Bordetella
/
Coqueluche
/
Génome bactérien
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Instituto Oswaldo Cruz-Fiocruz/BR
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