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Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis
Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Dagostin, Caroline S.; Simões, Lutiana R.; Vilela, Márcia C.; Comim, Clarissa M.; Petronilho, Fabricia; Quevedo, João; Teixeira, Antonio L..
  • Barichello, Tatiana; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Fagundes, Glauco D.; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Generoso, Jaqueline S.; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Dagostin, Caroline S.; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Simões, Lutiana R.; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Vilela, Márcia C.; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Comim, Clarissa M.; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Petronilho, Fabricia; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Quevedo, João; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
  • Teixeira, Antonio L.; Universidade do Extremo Sul Catarinense (UNESC). Laboratory of Experimental Microbiology. Criciúma. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 36(4): 322-329, Oct-Dec/2014. graf
Article Dans Anglais | LILACS | ID: lil-730589
ABSTRACT

Objective:

To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy.

Methods:

On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 × 106 CFU/mL and remained with their mothers until age 21 days. Animals were divided into the following groups control, control + EE, meningitis, and meningitis + EE. EE began at 21 days and continued until 60 days of age (adulthood). EE consisted of a large cage with three floors, ramps, running wheels, and objects of different shapes and textures. At 60 days, animals were randomized and subjected to habituation to the open-field task and the step-down inhibitory avoidance task. After the tasks, the hippocampus and CSF were isolated for analysis.

Results:

The meningitis group showed no difference in performance between training and test sessions of the open-field task, suggesting habituation memory impairment; in the meningitis + EE group, performance was significantly different, showing preservation of habituation memory. In the step-down inhibitory avoidance task, there were no differences in behavior between training and test sessions in the meningitis group, showing aversive memory impairment; conversely, differences were observed in the meningitis + EE group, demonstrating aversive memory preservation. In the two meningitis groups, IL-4, IL-10, and BDNF levels were increased in the hippocampus, and BDNF levels in the CSF.

Conclusions:

The data presented suggest that EE, a non-invasive therapy, enables recovery from memory deficits caused by neonatal meningitis. .
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Cytokines / Troubles de la cognition / Facteur neurotrophique dérivé du cerveau / Exposition environnementale / Troubles de la mémoire / Méningite à pneumocoques Type d'étude: Études d'évaluation / Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Thème du journal: Psychiatrie Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade do Extremo Sul Catarinense (UNESC)/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Cytokines / Troubles de la cognition / Facteur neurotrophique dérivé du cerveau / Exposition environnementale / Troubles de la mémoire / Méningite à pneumocoques Type d'étude: Études d'évaluation / Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Thème du journal: Psychiatrie Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade do Extremo Sul Catarinense (UNESC)/BR