Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
36(4): 340-343, Oct-Dec/2014. graf
Article
Dans Anglais
| LILACS
| ID: lil-730590
ABSTRACT
Objective:
To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).Methods:
Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).Results:
BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.Conclusion:
These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Trouble bipolaire
/
Facteurs de croissance nerveuse
Type d'étude:
Études d'évaluation
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Thème du journal:
Psychiatrie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Minas Gerais (UFMJ)/BR
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