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Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study
Ferreira, Érika Elias; Guerra, Daiane Cristina; Baluz, Kátia; Furtado, Wander de Resende; Bouzas, Luis Fernando da Silva.
  • Ferreira, Érika Elias; Instituto Nacional de Câncer José Alencar Gomes da Silva. Rio de Janeiro. BR
  • Guerra, Daiane Cristina; Instituto Nacional de Câncer José Alencar Gomes da Silva. Rio de Janeiro. BR
  • Baluz, Kátia; Instituto Nacional de Câncer José Alencar Gomes da Silva. Rio de Janeiro. BR
  • Furtado, Wander de Resende; Instituto Nacional de Câncer José Alencar Gomes da Silva. Rio de Janeiro. BR
  • Bouzas, Luis Fernando da Silva; Instituto Nacional de Câncer José Alencar Gomes da Silva. Rio de Janeiro. BR
Rev. bras. hematol. hemoter ; 36(6): 414-419, Nov-Dec/2014. tab
Article Dans Anglais | LILACS | ID: lil-731235
ABSTRACT

Objective:

This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge).

Methods:

A retrospective, descriptive and quantitative study was performed based on clinical, laboratory and nutritional data obtained from medical records of adult patients of both genders submitted to allogeneic hematopoietic stem cell transplantation in a bone marrow transplantation reference center in Rio de Janeiro in the period from 2010 to 2013. Statistical analysis was performed using the SPSS software (version 22.0).

Results:

Sixty-four patients were evaluated. The mean age was 42.1 ± 3.2 years and the most prevalent disease was acute myeloid leukemia (39%). There was a high prevalence of gastrointestinal symptoms including nausea (100%), vomiting (97%) and mucositis (93%). Between admission and discharge there was a significant decrease in the median weight (−2.5 kg; 71.5 vs. 68.75 kg; p-value < 0.001), body mass index (−0.9kg/m2; 24.8 vs. 24.4kg/m2; p-value < 0.001), and serum albumin levels (−0.2g/dL; 3.7 vs. 3.6g/dL; p-value = 0.024). The survival time after hematopoietic stem cell transplantation correlated negatively with C-reactive protein at discharge (CC = −0.72; p-value < 0.001) and positively with serum albumin levels (CC = 0.56; p-value = 0.004) and with high total protein level at discharge (CC = 0.53; p-value = 0.006).

Conclusion:

Our results suggest that patients submitted to allogeneic hematopoietic stem cell transplantation have compromised nutritional status during the hospital stay for transplantation...
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Transplantation homologue / État nutritionnel / Transplantation de cellules souches hématopoïétiques / Thérapie nutritionnelle Type d'étude: Étude observationnelle / Facteurs de risque Limites du sujet: Adolescent / Femelle / Humains / Mâle langue: Anglais Texte intégral: Rev. bras. hematol. hemoter Thème du journal: Hématologie Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Instituto Nacional de Câncer José Alencar Gomes da Silva/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Transplantation homologue / État nutritionnel / Transplantation de cellules souches hématopoïétiques / Thérapie nutritionnelle Type d'étude: Étude observationnelle / Facteurs de risque Limites du sujet: Adolescent / Femelle / Humains / Mâle langue: Anglais Texte intégral: Rev. bras. hematol. hemoter Thème du journal: Hématologie Année: 2014 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Instituto Nacional de Câncer José Alencar Gomes da Silva/BR