Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
Acta cir. bras
;
30(1): 73-79, 01/2015. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-735708
ABSTRACT
PURPOSE:
To evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats.METHODS:
Sixteen male rats were allocated across four groups LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis.RESULTS:
There were no differences in bursting pressure among groups LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation.CONCLUSION:
Obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cicatrisation de plaie
/
Cholestase extrahépatique
/
Côlon
/
Ictère rétentionnel
/
Glutamine
Type d'étude:
Études d'évaluation
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2015
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Brasilia University/BR
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